Fragment-Based Drug Discovery Market - Global Industry Analysis, Trends And Forecast 2015 - 2023

Fragment-based drug discovery (FBDD) is the phenomena of finding lead compounds during drug discovery procedure. It works on the principle of discovering small chemical fragments of drugs, which are weakly binded to the biological target and then these fragments are expanded or linked together to produce lead with larger affinity.

Fragment-based drug discovery is majorly used in the pharmaceutical industry as it provides intractable biological targets. FBDD is slowly replacing the high-throughput screening (HTS) with respect to chemical lead generation for drug targets. HTS screens molecules with molecular weight of 500 Da in comparison to which, FBDD screens the molecule with molecular weight of 200 Da hence providing the better results. On the basis of the techniques utilized for procedure, fragment-based drug discovery market is categorized into seven segments namely:

• X-ray crystallography
• Nuclear magnetic resonance (NMR) spectroscopy
• Surface plasmon resonance (SPR)
• Capillary electrophoresis
• Mass spectroscopy
• Differential scanning fluorimetry (DSF)
• Mass spectroscopy

Among these, X-ray crystallography followed by NMR is majorly used by major market players to screen the fragment-based libraries. As for instance, Proteros Biostructures GmbH and Sygnature Discovery are working together on commercial fragment screening services, whereby Proteros Biostructures GmbH provides structural validation of fragment binding modes through X-ray crystallography and Sygnature Discovery designs and synthesize novel fragments. Nuclear magnetic resonance spectroscopy is also used by many companies such as Evotech AG is using NMR spectroscopy for screening purposes of MK2 ligand because NMR proves out to be more efficient in observing resonances of protein directly.

Majorly two types of NMR spectroscopy are utilized for fragment-based drug discovery namely ligand detected NMR and protein detected NMR. Other than these various computation techniques such as docking software, post-docking analysis software and pharmacophore mapping software are also utilized for fragment-based drug discovery. 

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Fragment-based drug discovery market is growing at faster pace due to the extensive use of the technique for research and development in drug discovery. R&D through fragment-based drug discovery market has yielded a vast pipeline of FBDD derived assets which are undergoing clinical evaluation. Recently, Plexicon’s product vemurafenib, drug used to treat late stage melanoma has been approved by the Food and Drug Association. Other than this, many drugs such as ABT869, AT9283 and DG-051 are currently under phase 2 and phase 3 clinical trials. Higher ligand efficiency, more hydrophilic hits and less containment of sterically blocking groups are other factors that are also helping the market to grow. Fragment-based drug delivery market is also facing few restraints due to the need for highly sensitive screening devices and high cost involved with the procedure. 

Companies based in North America and Europe has shown major interest in fragment-based drug discovery market majorly due to high government support towards research and development activities and availability of suitable infrastructure. As for example Abbott Laboratories has recently developed the drugs using fragment-based drug discovery which is focused on treating leukemia and liver cancer. These drugs are currently under phase II clinical trials. Asia-Pacific market is also growing at rapid rate due to increasing research and development activities in some countries such as Japan, China, Korea and India. 

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Some of the major market players in fragment-based drug discovery market include Astex Pharmaceuticals, BioPredict, Inc., Locus Pharmaceuticals, Cell Therapeutics, Inc., Schering-Plough Corporation, GlaxoSmithKline plc, deCODE Genetics, Eli Lilly and Company, Novaratis AG and Vernalis. 

This research report analyzes this market on the basis of its market segments, major geographies, and current market trends. Geographies analyzed under this research report include 

• North America 
• Asia Pacific 
• Europe
• Middle East and Africa
• Latin America

This report provides comprehensive analysis of 

• Market growth drivers 
• Factors limiting market growth
• Current market trends 
• Market structure
• Market projections for upcoming years 

This report is a complete study of current trends in the market, industry growth drivers, and restraints. It provides market projections for the coming years. It includes analysis of recent developments in technology, Porter’s five force model analysis and detailed profiles of top industry players. The report also includes a review of micro and macro factors essential for the existing market players and new entrants along with detailed value chain analysis. 

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