D-dimer Testing Market poised to achieve significant growth by 2022

The medical industry today is geared toward diagnosing conditions in an accurate yet timely manner via the heightened use of in vitro diagnostic tools. Using these tools, it is possible for medical practitioners to screen, diagnose, stage, and manage diseases to prescribe the right drugs in the right doses. Similarly, the D-dimer test is now widely used to screen for and diagnose thrombosis so that medical practitioners can take a better decision about whether or not a patient suffers from conditions such as deep vein thrombosis (DVT), disseminated intravascular coagulation (DIC), or pulmonary embolism (PE). This has created a multibillion-dollar global D-dimer tests market.

Demand for D-dimer tests has substantially increased due to its accuracy, cost effectiveness, and lack of radiological interventions. Despite its increased demand, D-dimer is not used as a confirmatory test, but mostly used to confirm the exclusion of the mentioned condition i.e., when a patient is suffering from a coagulation disorder, and not illustrating the type of the disorder such as DVT, PE, or DIC. The global market for D-dimer testing is segmented broadly into testing methods and applications. The point-of-care test segment includes rapid diagnostic kits, whereas the laboratory test segment comprises reagents and assays employed for analyzing the presence of D-dimer in blood sample.

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In terms of accurate quantitative estimation of D-dimer, laboratory-based analysis is a robust technique as compared to point-of-care test. Moreover, laboratory-based test can be paramount in not only identifying individuals who are at a risk of first thrombotic event, but also detecting the chances of having a recurrent VTE. Overall, the drawbacks associated with laboratory test include need for adequate space to set up and high response time (40 minutes to 50 minutes) as compared to POC tests (10 minutes to 15 minutes). The laboratory test segment has been sub-segmented into coagulation analyzers and clinical chemistry analyzers.

The global D-dimer testing market can be broadly segmented on the basis of various testing methods, applications, as well as geographical region. The key testing methods comprise: Point-of-care and laboratory tests. While the latter has conventionally been the testing method of choice of in the D-dimer testing market, the former is now gaining momentum to potentially emerge as the leading segment in the market. Point-of-care D-dimer testing presents healthcare providers with several desirable options such as convenience, rapid turnaround time, and accurate results. They thus accelerate the entire screening, diagnosis or treatment method.  The most commonly-seen diseases where D-dimer testing is used are: DIC, PE, and DVT.

The global D-dimer testing market has several factors that work in its favor. The most important among these are: A marked increase in patients undergoing coagulation testing, cutting-edge technological breakthroughs (such as sensitive hemostasis markers compatible with automated instruments), and the need to monitor patients undergoing anti-coagulation therapy.

Major growth drivers for the global D-dimer testing market include rise in the number of patients demanding coagulation testing, various technological advancements such as introduction of highly sensitive and specific hemostasis markers for automated instruments, and monitoring of patients on anti-coagulation therapy. However, interpretation of D-dimer levels in the aged population remains a major challenge. This has been attributed to the dramatic increase in rate of thrombosis with age, thus rendering D-dimer test less useful in excluding DVT or PE. Clinical acceptance of point-of-care D-dimer tests by hospitals and clinics is another obstacle in the market growth. Poor bioequivalence compared to laboratory services raises concerns regarding the acceptability of POC device in emergency departments. Since last few years, detection of PE based on clinical symptoms has become complicated demanding the development of fully automated coagulation analyzers capable of running tests based on multiple methods with increased safety, precision, and accuracy compared with manual methods.

On the flip side, it is still considered a challenge to accurately interpret the levels of D-dimer among the geriatric population. The key factor behind this is the spiraling rate of age-related thrombosis. In such conditions, the efficacy of D-dimer tests is reduced by several degrees in excluding PE or DVT. Also, the point-of-care D-dimer testing market is still struggling to gain widespread acceptance in both small clinics and larger hospitals because they are not perceived to offer the same degree of bioequivalence as lab services. This is especially seen to be the case in emergency departments.Overall, the global D-dimer testing market is expected to register a somewhat tepid CAGR of 2.6% between 2014 and 2022 to stand at US$ 1.9 billion by 2022.

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