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Alpha-1 Antitrypsin Deficiency is Set to Grow Significantly in Upcoming Years- BIS Research

The global alpha-1 antitrypsin deficiency (AATD) market is set for significant growth from 2024 to 2035, driven by increasing therapy demand, diagnostic advancements, and rising awareness. North America leads the market, with recent developments including FDA-approved base-editing therapies and Sanofi’s acquisition of Inhibrx for advanced treatments. Challenges like high treatment costs and limited awareness in emerging markets may impact growth.
Published 17 June 2025

What is a Alpha-1 Antitrypsin Deficiency? 

Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that leads to low levels of alpha-1 antitrypsin (AAT), a protein that helps protect the lungs and liver from damage. This deficiency can result in lung diseases such as emphysema and chronic obstructive pulmonary disease (COPD), as well as liver problems. 

What is the Current Market Outlook for Alpha-1 Antitrypsin Deficiency ? 

The global alpha-1 antitrypsin deficiency market is projected to grow significantly from 2024 to 2035, driven by increased demand for therapies, advancements in diagnostic technologies, and growing awareness among patients and healthcare providers. 

What is the key Innovation & Trends in Alpha-1 Antitrypsin Deficiency Market? 

Key trends include the development of innovative therapies such as gene therapies and base-editing treatments, alongside advancements in diagnostic technologies like genetic testing. These innovations aim to improve early diagnosis and treatment outcomes. 

How Does This Report Help Organizations Drive Strategic Growth? 


  • Market Growth Insight: Provides projections for the AATD market, helping to forecast future opportunities. 
  • Treatment Trends: Identifies key therapies driving market demand, aiding strategic planning. 
  • Regional Focus: Highlights North America's leadership, useful for targeting key markets. 


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What Are the Key Demand Drivers, and Challenges in the Alpha-1 Antitrypsin Deficiency Market? 


Drivers: 

•    Increasing Awareness and Early Diagnosis 

•    Advancements in Treatment Options 

Challenges: 

•    High Treatment Costs 

•    Limited Awareness in Emerging Markets 

What is the Market Segmentation in Alpha-1 Antitrypsin Deficiency Market? 

Based on Treatment 

•    Augmentation Therapy 

•    Bronchodilators 

•    Corticosteroids 

•    Oxygen Therapy 

Based on Distribution Channel 

•    Hospitals Pharmacy 

•    Retail Pharmacies 

•    Online Pharmacies 

Based on Region 

•    North America 

•    Europe 

•    Asia-Pacific 

•    Rest-of-the-World 


What Is the Competitive Landscape in Alpha-1 Antitrypsin Deficiency Market?

 

Key Players 

•    Grifols  

•    CSL Behring  

•    Kamada Pharmaceuticals 

•    Takeda  

•    LFB Biotechnologies 

•    Arrowhead Pharmaceuticals  

•    Mereo BioPharma/AstraZeneca 

•    Sanofi/Inhibrx Biosciences 

•    GlaxoSmithKline plc 

•    AstraZeneca 

•    Merck 

•    Pfizer Inc. 


Strategic Initiatives 

To capitalize on the growing alpha-1 antitrypsin deficiency (AATD) market, stakeholders should focus on expanding treatment access through strategic partnerships and leveraging advancements in diagnostic technologies. Key actions include targeting regions with high demand, especially North America, where infrastructure and awareness are strong, and investing in innovative therapies such as base-editing treatments and subcutaneous options to improve patient outcomes and adherence. 

Here Are Some Case Studies and Success Stories in Alpha-1 Antitrypsin Deficiency Market 

In 2024, a leading pharmaceutical company partnered with a biotechnology firm to develop a recombinant human AAT-Fc fusion protein, INBRX-101. Following Sanofi's acquisition of Inhibrx, this therapy aims to normalize serum AAT levels with less frequent dosing, offering a major advancement in AATD treatment. This collaboration showcases how strategic acquisitions and R&D investments can significantly enhance treatment options and market positioning in the AATD space. 

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About BIS Research 

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Our strategic market analysis emphasizes market estimations, technology analysis, emerging high-growth applications, deeply segmented granular country-level market data, and other important market parameters useful in the strategic decision-making for senior management.    

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