U.S. Next-Generation Sequencing Library Preparation Market to Hit USD 2,167.71 Million by 2034 Growing at a CAGR of 12.83%

The newly published market research report by Polaris Market Research, titled U.S. Next-Generation Sequencing Library Preparation Market Size, Share, Trends, Industry Analysis Report By Sequencing Type (Targeted Genome Sequencing, Whole Genome Sequencing), By Product, By Application, By End Use – Market Forecast, 2025–2034, offers an in-depth examination of the highly dynamic sector. It provides a holistic view of the market’s current state, including size, share, and competitive landscape. Additionally, it reveals the factors that will influence its future trajectory. The report includes segmentation, regional breakdowns, and technological assessments to help readers identify emerging trends, growth opportunities, and key risks. It combines primary interviews, secondary data sources, and expert analysis, serving as a strategic guide for industry stakeholders, investors, policymakers, and market entrants. Whether you are entering the market, expanding operations, or monitoring competitive shifts, this report is a valuable tool for understanding how the U.S. Next-Generation Sequencing Library Preparation Market is positioned today and where it is headed in the coming years.

What is U.S. Next-Generation Sequencing Library Preparation Market?

The U.S. Next-Generation Sequencing (NGS) Library Preparation Market is witnessing significant growth due to the increasing demand for high-throughput sequencing in clinical and research applications. Rising adoption of precision medicine and advancements in genomics technologies are fueling market expansion. Automation and kit-based library prep solutions are gaining popularity for their efficiency and reproducibility. The growing focus on biomarker discovery and cancer diagnostics further propels demand. Additionally, government support and increased R&D investments in molecular diagnostics support market growth. Companies are innovating to simplify workflows and reduce turnaround times.

What Are Key Market Statistics?

The U.S. Next-Generation Sequencing (NGS) Library Preparation Market is currently valued at USD 649.42 million in 2024 and is projected to reach approximately USD 2,167.71 million by 2034, according to recent research by Polaris Market Research. The market is expected to grow at a strong compound annual growth rate (CAGR) of 12.83% during the forecast period from 2025 to 2034. Key growth drivers include the rising prevalence of rare diseases, increased healthcare expenditure, the presence of leading industry players, and expanding investments in cancer research initiatives.

What Are the Key Forces Shaping the Market Landscape?

Understanding the forces that influence the growth, direction, and transformation of the market is essential for strategic planning and forecasting. This section provides a detailed evaluation of all key factors shaping the U.S. Next-Generation Sequencing Library Preparation Market landscape.

These include:

• Rising demand for precision medicine and genomic research
• Technological advancements in sequencing platforms
• Growth in clinical diagnostics and cancer genomics
• Increased investment in personalized healthcare

𝐆𝐞𝐭 𝐄𝐱𝐜𝐥𝐮𝐬𝐢𝐯𝐞 𝐒𝐚𝐦𝐩𝐥𝐞 𝐏𝐚𝐠𝐞𝐬 𝐨𝐟 𝐓𝐡𝐢𝐬 𝐑𝐞𝐩𝐨𝐫𝐭:

https://www.polarismarketresearch.com/industry-analysis/us-next-generation-sequencing-library-preparation-market/request-for-sample

Who Are the Leading Market Players?

The report provides a comprehensive assessment of the competitive landscape in the U.S. Next-Generation Sequencing Library Preparation Market, highlighting key market players, their market strategies, product/service portfolios, and recent developments. It outlines market concentration, the relative positioning of companies, and the degree of competitive intensity. Mergers and acquisitions, partnerships, expansions, technological innovations, and other strategic moves are covered to help readers understand how companies are responding to evolving market dynamics. This section typically includes company profiles, SWOT analyses, and market share information, providing stakeholders with a detailed view of the competitive landscape.

• Agilent Technologies, Inc.
• BD
• Hoffmann-La Roche AG, Inc.
• Illumina, Inc.
• New England Biolabs Inc.
• Oxford Nanopore Technologies
• Pacific Biosciences of California, Inc.
• QIAGEN N.V.
• Revvity, Inc.
• Thermo Fisher Scientific Inc.
• Twist Bioscience

The U.S. next-generation sequencing (NGS) library preparation market for epigenetic changes includes various sequencing types such as whole-genome bisulfite sequencing (WGBS), reduced representation bisulfite sequencing (RRBS), ChIP-Seq, and ATAC-Seq. These methods enable comprehensive analysis of DNA methylation, histone modifications, and chromatin accessibility. The demand for these sequencing types is driven by increasing research into epigenetic mechanisms in disease, particularly cancer. Advances in library preparation technologies are improving the accuracy and efficiency of epigenetic profiling. Key market players are focusing on developing streamlined, high-throughput solutions tailored for epigenetic studies. Overall, the segment is experiencing steady growth due to its critical role in advancing precision medicine and biomarker discovery.

Urbanization and Evolving Consumer Lifestyles:

Rapid urbanization and shifting consumer behavior are creating a heightened demand for efficient and scalable solutions. The report examines how increasing urban populations and rising disposable incomes are influencing consumption patterns and encouraging the adoption of next-generation products and services. It also examines how companies are tailoring their offerings to meet the specific needs of urban dwellers.

Supportive Regulatory and Policy Environment:

Government interventions and regulatory frameworks play a pivotal role in shaping market dynamics. The report assesses the impact of supportive policies, investment incentives, and streamlined licensing procedures on market expansion. It also considers how global and regional regulations are driving the pursuit of standardization, safety, and innovation, thereby fostering a more competitive and investor-friendly environment.

• The FDA’s support for genomic testing and accelerated approval pathways for NGS-based diagnostics boosts adoption.
• NIH and other federal agencies continue funding large-scale genomic research, fostering demand for sequencing library preparation tools.

How Is the Market Structured Across Different Segments?

This report provides a comprehensive segmentation of the U.S. Next-Generation Sequencing Library Preparation Market. It offers an in-depth breakdown across multiple segments, including By Type (Environmental Advisory, Social Responsibility Advisory), By Application, By Industry, By Size. Each segment has been thoroughly analyzed to assess its contribution to overall market value, current adoption levels, historical performance, and expected growth trajectory over the forecast period. The market segmentation aims to uncover specific growth pockets and demand centers. That way, stakeholders can better understand which categories are expanding, which are maturing, and which may be emerging in response to shifting market conditions. By examining each segment through both quantitative metrics and qualitative insights, the report equips readers with actionable intelligence. The structured approach helps businesses assess segment attractiveness, prioritize resource allocation, and develop tailored strategies for product development and geographic expansion.

U.S. Next-Generation Sequencing Library Preparation Market, Sequencing Type Outlook (Revenue - USD Million, 2020-2034)

• Targeted Genome Sequencing
• Whole Genome Sequencing
• Whole Exome Sequencing
• Other

U.S. Next-Generation Sequencing Library Preparation Market, Product Outlook (Revenue - USD Million, 2020-2034)

• Reagents & Consumables
• DNA Library Preparation Kits
• RNA Library Preparation Kits
• Other
• Instruments

U.S. Next-Generation Sequencing Library Preparation Market, Application Outlook (Revenue - USD Million, 2020-2034)

• Drug & Biomarker Discovery
• Disease Diagnostics
• Cancer Diagnostics
• Reproductive Health Diagnostics
• Infectious Disease Diagnostics
• Other
• Others

U.S. Next-Generation Sequencing Library Preparation Market, End Use Outlook (Revenue - USD Million, 2020-2034)

• Hospitals and Clinics
• Academic and Research Institutions
• Pharmaceutical and Biotechnology Companies
• Others

𝐄𝐱𝐩𝐥𝐨𝐫𝐞 𝐓𝐡𝐞 𝐂𝐨𝐦𝐩𝐥𝐞𝐭𝐞 𝐂𝐨𝐦𝐩𝐫𝐞𝐡𝐞𝐧𝐬𝐢𝐯𝐞 𝐑𝐞𝐩𝐨𝐫𝐭 𝐇𝐞𝐫𝐞:

https://www.polarismarketresearch.com/industry-analysis/us-next-generation-sequencing-library-preparation-market

What External Factors Influence the Market Environment?

The report includes a comprehensive PESTEL analysis to examine the macro-environmental factors influencing the U.S. Next-Generation Sequencing Library Preparation Market across different regions. This framework assesses the political, economic, social, technological, environmental, and legal factors that collectively influence market conditions and strategic decision-making. Political factors consider the impact of trade policies, taxation, and international relations on market access and operational risk. Economic aspects cover factors that affect purchasing power, production costs, and investment flows. Social trends have been analyzed to understand evolving demand patterns. Technological factors assess the pace of innovation, R&D activity, automation, and the adoption of new platforms or production methods. Environmental considerations, including climate change regulations, resource availability, and eco-conscious practices, are increasingly influencing business strategies. Lastly, the Legal dimension examines regulatory frameworks, compliance requirements, and intellectual property laws that govern market participation.

How Do Different Regions Impact Market Growth and Opportunities?

The report provides a comprehensive regional outlook, examining how geographic variations influence the U.S. Next-Generation Sequencing Library Preparation Market dynamics across major global regions. This section provides an in-depth assessment of key regions, highlighting differences in market maturity, regulatory environments, consumer behavior, economic development, and industrial activity. For each region, the report examines macroeconomic indicators to assess the underlying market readiness. It also explores region-specific policies, trade agreements, and government initiatives that influence demand, manufacturing practices, and import/export activities. The analysis evaluates competitive intensity within each region by profiling the presence of leading companies and emerging local players. This granular perspective enables businesses to identify high-growth territories and align their go-to-market plans with local dynamics.

What is the Market Report Scope?

The report begins by establishing the foundational context of the U.S. Next-Generation Sequencing Library Preparation Market. It outlines the relevance of the market within the broader economic and industrial landscape. This section also outlines the study's objectives, target audience, data sources, and research methodology, encompassing both primary and secondary research techniques. The scope of the report covers historic data trends, base year analysis, and forward-looking forecasts. It further clarifies the market boundaries in terms of geography, solution types, applications, and end-users that will be explored in the following sections.

About Polaris Market Research

Polaris Market Research is a global market research and consulting company. The company specializes in providing exceptional market intelligence and in-depth business research services for clientele spread across different enterprises. We at Polaris are obliged to serve our diverse customer base present across the industries of healthcare, technology, semiconductors, and chemicals among various other industries present around the world. We strive to provide our customers with updated information on innovative technologies, high-growth markets, emerging business environments, and the latest business-centric applications, thereby empowering them to make informed decisions and leverage new opportunities. Adept with a highly competent, experienced, and extremely qualified team of experts comprising SMEs, analysts, and consultants, we strive to deliver value-added business solutions tailored to our clients’ strategic goals.

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