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Systemic Sclerosis Market Set to Reach by 2035 – BIS Research

The global systemic sclerosis market is on a strong growth trajectory, with BIS Research projecting significant expansion between 2024 and 2035. Growth is underpinned by increasing awareness, earlier diagnosis enabled by advanced imaging and biomarkers, and the wider adoption of targeted therapies such as biologics and antifibrotics.
Published 11 September 2025

What Is Systemic Sclerosis? 

Systemic sclerosis, or scleroderma, is a rare autoimmune disease that causes fibrosis of the skin and internal organs. The condition can result in severe complications including interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH). Advances in diagnostics, genetic testing, and biomarkers are enabling earlier detection, while new treatment classes are enhancing long-term patient management. 

What Is the Market Outlook? 

Technology Growth: Greater use of imaging, biomarker testing, and AI-powered disease prediction models. 

Expanding Clinical Applications: Broader adoption of immunosuppressants, antifibrotics, and biologics in treating ILD, PAH, and systemic sclerosis–related complications. 

Commercialization Push: Leading pharmaceutical companies investing heavily in clinical trials and expanding pipelines for novel therapies. 

How Fast Is the Market Growing? 

The systemic sclerosis market, which begins at a significant baseline in 2024, is set to reach by 2035. The upward trajectory reflects sustained demand for advanced therapies, improved patient access, and adoption of precision medicine across global healthcare systems. 

How Will This Report Help You? 

Planning to Enter the Market? 

Explore opportunities in biologics, antifibrotics, and immunosuppressive therapies. 

Analyzing the Competitive Landscape? 

Gain insights into strategies of key players such as Roche, Boehringer Ingelheim, and Sanofi. 

Seeking R&D Insights? 

Track pipeline innovations in antifibrotic drugs, AI-powered diagnostics, and digital disease monitoring. 

Interested in Regional Market Trends? 

Review adoption dynamics, reimbursement models, and regulatory landscapes shaping systemic sclerosis management. 

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What Technologies Are Transforming the Market? 


  • Advanced Imaging and Biomarker-Based Testing 
  • AI-Powered Predictive Analytics 
  • Biologics and Antifibrotic Drug Classes 
  • Remote Monitoring and Telemedicine Platforms 
  • Personalized Genomics-Based Interventions 


What’s Driving Demand, Opportunities, and Barriers? 

Demand Drivers 

  • Rising prevalence of systemic sclerosis worldwide 
  • Earlier and more accurate diagnosis with biomarkers and imaging 
  • Increasing approvals and adoption of biologics and antifibrotics 

Opportunities 

  • Expansion of digital health and telemedicine services 
  • Growth of systemic sclerosis trials in emerging markets 
  • Integration of systemic sclerosis management into personalized medicine 

Challenges 

  • High treatment costs and limited reimbursement access 
  • Few disease-specific therapies available 
  • Variable disease progression complicating standardized treatment 


Key Players 


  • Hoffmann-La Roche Ltd. 
  • Boehringer Ingelheim GmbH 
  • Sanofi S.A. 
  • Actelion Pharmaceuticals Ltd. 
  • Corbus Pharmaceuticals Holdings, Inc. 
  • Bayer AG 
  • Viatris 
  • Acceleron Pharma Inc. 
  • Incyte Corporation 
  • Pfizer 
  • Others 


Strategic Developments 


  • Expansion of antifibrotic and biologic pipelines through acquisitions and collaborations 
  • Strong investment in digital health platforms for patient monitoring 
  • Ongoing global clinical trials targeting ILD and PAH in systemic sclerosis patients 
  • Partnerships to improve patient access and awareness 


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Case Study 

The report highlights real-world examples where systemic sclerosis patients benefit from immunosuppressants for inflammation control, antifibrotics for lung fibrosis, and digital health tools that track adherence. These approaches are enabling earlier intervention, slowing disease progression, and improving quality of life through more personalized treatment strategies. 

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Related Reports from BIS Research 

Hepatic Encephalopathy Market 

Fuchs Endothelial Corneal Dystrophy Market 

Familial Chylomicronemia Syndrome Market 


About BIS Research  

BIS Research is a global B2B market intelligence and advisory firm focusing on deep technology and related emerging trends, which can disrupt the market dynamics in the near future. We publish over 200 market intelligence studies annually, focusing on several deep technology verticals.    

Our strategic market analysis emphasizes market estimations, technology analysis, emerging high-growth applications, deeply segmented granular country-level market data, and other important market parameters useful in the strategic decision-making for senior management.     

BIS Research offers syndicate and custom studies and expert consultations to firms, providing them with specific and actionable insights on novel technology markets, business models, and competitive landscapes.    


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