Health & Safety Industry Today

Protein Sequencing Market is Expected to Reach $2,697.0 million by 2033- BIS Research

The global protein sequencing market is projected to grow from $1,749.0 million in 2023 to $2,697.0 million by 2033, at a CAGR of 4.36%. This growth is fueled by rising demand for personalized medicine, where understanding protein structures and modifications is key to identifying biomarkers and developing targeted therapies. Protein sequencing plays a vital role in drug discovery, enabling the identification of new drug targets and supporting the development of biologics, including monoclonal antibodies and therapeutic proteins making it essential for advancing precision healthcare and biopharmaceutical innovation.
Published 27 May 2025

Market Overview 


Market Size and Growth 

The global protein sequencing market is expected to grow from $1,749.0 million in 2023 to $2,697.0 million by 2033, at a CAGR of 4.36%. This steady growth is fueled by rising investments in personalized medicine, increasing demand for targeted therapies, and expanding use of protein sequencing in drug discovery. Biopharmaceutical companies are leveraging sequencing data to develop monoclonal antibodies and therapeutic proteins, while academic and research institutions rely on these technologies for biomarker identification and disease mechanism studies. 

Trends and Innovation 

Technological advancements in mass spectrometry, reagents, and sample preparation tools are enhancing the precision and throughput of protein sequencing. The shift toward personalized and preventive medicine is accelerating demand for advanced protein analysis, particularly in oncology, neurology, and cardiovascular care. Service providers, including CROs, are expanding offerings in protein identification and post-translational modification analysis, catering to both pharma and academic sectors. Growth is especially prominent in North America and Asia-Pacific, where innovation, healthcare investments, and research activity are driving the market forward. 

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Key Highlights 


Report USP 


  • Detailed regional insights and competitive benchmarking. 
  • Comprehensive analysis of demand drivers, challenges, and growth opportunities. 
  • Extensive regional segmentation and profiles of leading players. 


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Demand Drivers, Challenges and Opportunities 


Demand Drivers 

The protein sequencing market is advancing rapidly, fueled by innovations in computational biology and bioinformatics. These technologies are critical in areas like drug discovery, proteomics research, and biomarker development. By employing advanced algorithms and extensive biological data, they refine protein sequence analysis and design, improving the precision and effectiveness of sequencing techniques. 

Challenges 

A shortage of qualified professionals presents a major obstacle for the protein sequencing market. The process demands in-depth knowledge of biochemistry, molecular biology, and specialized analytical methods. Expertise is required to operate high-precision instruments such as mass spectrometers and to handle the complex computational tasks involved in processing and interpreting large-scale sequencing data. 

Opportunities 

Artificial intelligence is creating promising prospects in protein sequencing. Machine learning applications, paired with cutting-edge materials like solid-state 2D phosphorene nanoslit devices, are driving innovation in molecular diagnostics. These advancements are enabling rapid and highly accurate amino acid identification at the single-molecule level, overcoming challenges associated with high-throughput sequencing and paving the way for improved therapeutic solutions. 


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Market Segmentation 

Segmentation 1: based on Product and Service 

•    Product 

•    Service 

Segmentation 2: based on Application 

•    Biotherapeutics 

•    Genetic Engineering 

•    Others 

Segmentation 3: based on Sample Type 

•    Biological Sample 

•    Tissue Sample 

•    Cultured Cell 

•    Other Samples 

Segmentation 4: based on Technology 

•    Mass Spectrometry 

•    Edman Degradation 

•    Other Technologies 

Segmentation 5: based on End User 

•    Academic Institutes 

•    Pharma and CROs 

•    Biotech, Diagnostics, and Other Companies 

Segmentation 6: based on Region 

•    North America 

      o    U.S. 

      o    Canada 

•    Europe 

      o    Germany 

      o    U.K. 

      o    France 

      o    Italy 

      o    Spain 

      o    Rest-of-Europe 

•    Asia-Pacific 

      o    China 

      o    Japan 

      o    India 

      o    Australia 

      o    South Korea 

      o    Rest-of-Asia-Pacific 

•    Latin America 

      o    Brazil 

      o    Mexico 

      o    Rest-of-Latin America 

•    Rest-of-the-World 


Competitive Landscape  


Key Players  

•    Agilent Technologies, Inc. 

•    Bio-Rad Laboratories, Inc. 

•    Thermo Fisher Scientific, Inc. 

•    Shimadzu Corporation 

•    Charles River Laboratories 

•    Selvita 

•    Bruker Corporation 

•    Merck KGaA 

•    Seer, Inc. 

•    FUJIFILM Holdings Corporation 


Strategic Initiatives 

Leading companies in the protein sequencing sector are actively pursuing strategies to enhance their market presence and technological capabilities. These initiatives include investments in research and development to innovate sequencing technologies, collaborations with academic and research institutions to advance proteomics studies, and efforts to expand into emerging markets where demand for protein analysis is growing. Such strategic moves aim to address the increasing global emphasis on personalized medicine and the need for detailed protein characterization in drug discovery and development. 


Case Study and Success Story 

A significant development involved a major protein sequencing company partnering with a leading pharmaceutical firm to co-develop advanced sequencing platforms tailored for biopharmaceutical applications. This collaboration focuses on integrating cutting-edge sequencing technologies into the drug development pipeline, enabling more precise identification of therapeutic targets and biomarkers. The partnership has led to accelerated development timelines and improved efficacy in therapeutic interventions, demonstrating the value of strategic alliances in advancing the protein sequencing field. 


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Related Reports from BIS Research 

Mass Spectrometry and Chromatography in Diagnostics  

Protein Expression    

3D Protein Structure Analysis  


About BIS Research 

BIS Research is a global B2B market intelligence and advisory firm focusing on deep technology and related emerging trends, which can disrupt the market dynamics in the near future. We publish over 200 market intelligence studies annually, focusing on several deep technology verticals.   

Our strategic market analysis emphasizes market estimations, technology analysis, emerging high-growth applications, deeply segmented granular country-level market data, and other important market parameters useful in the strategic decision-making for senior management.    

BIS Research offers syndicate and custom studies and expert consultations to firms, providing them with specific and actionable insights on novel technology markets, business models, and competitive landscapes.   

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