Gene Therapy for Age-Related Macular Degeneration Market to Achieve USD 5 Billion, Growing at 13.1% CAGR by 2035

WiseGuy Reports, Sept. 2025 (Press Release) – The Gene Therapy for Age-Related Macular Degeneration Market Global Outlook:

Gene Therapy for Age-Related Macular Degeneration Market Size, Share & Industry Analysis By Therapeutic Approach (Adeno-Associated Virus, CRISPR/Cas9, RNA Interference, Stem Cell Therapy), By Indication (Geographic Atrophy, Neovascular Age-Related Macular Degeneration, Dry Age-Related Macular Degeneration), By Route of Administration (Intravitreal Injection, Subretinal Injection, Systemic Administration), By End User (Hospitals, Specialist Clinics, Research Institutions) and Regional Forecasts, 2025-2035

Key Profits for Gene Therapy for Age-Related Macular Degeneration Market Industry Top Members and Stakeholders:

1. The Gene Therapy for Age-Related Macular Degeneration Market report includes a plethora of information such as market dynamics scenario and opportunities during the forecast period.

2. Which regulatory trends at corporate-level, business-level, and functional-level strategies.

3. Which are the End-User technologies being used to capture new revenue streams in the near future.

4. The competitive landscape comprises share of key players, new developments, and strategies in the last three years.

5. One can increase a thorough grasp of Gene Therapy for Age-Related Macular Degeneration Market dynamics by looking at prices as well as the actions of producers and users.

6 Comprehensive companies offering products, relevant financial information, recent developments, various Industry analysis methods, and strategies by these top players. 

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The Gene Therapy for Age-Related Macular Degeneration Market is gaining momentum as breakthroughs in biotechnology, rising prevalence of AMD, and advancements in gene delivery systems converge. Valued at USD 1.3 billion in 2024, the market is projected to reach USD 1.5 billion in 2025 and accelerate to USD 5.0 billion by 2035. A CAGR of 13.1% between 2025 and 2035 underscores strong growth potential for pharmaceutical companies, biotech firms, healthcare providers, and investors.

Market Overview

Historical data from 2019 to 2023 demonstrates gradual adoption of gene therapy in ophthalmology across North America, Europe, APAC, South America, and MEA. The Gene Therapy for Age-Related Macular Degeneration Market is now transitioning from experimental therapies to commercially viable solutions.

The market’s scope spans therapeutic approaches, indications, routes of administration, end users, and regional distribution. As gene therapy progresses from clinical trials to real-world applications, it offers long-term treatment solutions for patients, reducing reliance on repetitive injections and improving quality of life.

Key Market Dynamics

The Gene Therapy for Age-Related Macular Degeneration Market is shaped by several critical dynamics. Increasing prevalence of AMD, particularly among the aging population, is driving higher demand for innovative treatments. With millions worldwide affected by vision impairment, unmet clinical needs remain high.

Growing investment in R&D supports pipeline expansion, as companies advance novel vectors, delivery mechanisms, and combination therapies. Regulatory support and accelerated approval pathways further encourage innovation.

Consumer and patient awareness is rising, leading to higher acceptance of cutting-edge therapies. Meanwhile, advancements in gene delivery systems, such as adeno-associated viral (AAV) vectors, are enabling safer and more efficient outcomes.

Segmentation Insights

The Gene Therapy for Age-Related Macular Degeneration Market is segmented across therapeutic approach, indication, route of administration, end user, and regional scope.

Therapeutic approaches include anti-VEGF gene therapies, optogenetics, and genome editing-based solutions. Indications cover wet and dry AMD, both presenting significant treatment challenges. Routes of administration focus on intravitreal and subretinal injections, with new minimally invasive methods under exploration.

End users span hospitals, specialized ophthalmology clinics, and research institutions. Regionally, North America and Europe lead adoption, supported by strong regulatory frameworks and established biotech ecosystems. APAC represents the fastest-growing market, driven by aging demographics and rising healthcare investments in China, Japan, and India. South America and MEA provide long-term opportunities with growing access to advanced therapies.

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Competitive Landscape

The Gene Therapy for Age-Related Macular Degeneration Market is highly competitive, featuring global leaders and emerging biotech innovators. Key companies include Novartis, Sana Biotechnology, Avexis, MediGene, Opthea, Spark Therapeutics, Editas Medicine, Xilio Therapeutics, Regenxbio, GenSight Biologics, Sarepta Therapeutics, Cambridge Cognition, Horizon Therapeutics, Nightstar Therapeutics, and Astellas Pharma.

These companies are investing heavily in clinical trials, strategic collaborations, and advanced delivery platforms. Partnerships between large pharmaceutical corporations and niche biotech firms accelerate commercialization and expand access to new therapies.

Opportunities for B2B Stakeholders

The Gene Therapy for Age-Related Macular Degeneration Market presents vast opportunities for stakeholders. Expansion of clinical trial initiatives provides CROs, research institutions, and healthcare providers with avenues to collaborate. Innovations in delivery mechanisms open new markets for device manufacturers and technology enablers.

Partnerships with biotech firms offer strategic benefits for pharma companies seeking pipeline diversification. The growing elderly population worldwide ensures sustainable demand, while increasing awareness of gene therapy creates favorable adoption trends.

For investors, the market represents a high-growth, innovation-driven space. For distributors and healthcare providers, integrating gene therapy into ophthalmology services enhances patient outcomes and differentiates service offerings.

Market Outlook

The outlook for the Gene Therapy for Age-Related Macular Degeneration Market is one of transformation. With revenues forecasted to reach USD 5.0 billion by 2035, the industry is positioned for long-term growth.

The convergence of advanced gene-editing technologies, robust R&D pipelines, and regulatory support signals a paradigm shift in ophthalmic care. Companies that prioritize innovation, sustainable partnerships, and patient-centric delivery models will capture significant value.

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➼ Historical and future market research in terms of size, share growth, volume, and sales.

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➼ Key business strategies by major market players and their key methods

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