CircRNA Synthesis Market to Surge to USD 592.84 Million by 2032 Driven by RNA-Based Therapeutics and Advanced Synthesis Technologies

CircRNA Synthesis Market Overview

The global CircRNA synthesis market was valued at USD 183.58 million in 2024 and is projected to reach USD 592.84 million by 2032, growing at a CAGR of 15.85% during 2025-2032. Circular RNAs (circRNAs) are emerging as vital molecules in gene regulation, biomarker discovery, and therapeutic applications. Their remarkable stability and regulatory roles have drawn attention from both academic and commercial research, driving the adoption of circRNA synthesis platforms.

North America leads the market with the U.S. accounting for USD 62.32 million in 2024, expected to reach USD 198.32 million by 2032, due to advanced biotech infrastructure, high R&D funding, and strong academic-industry collaborations.

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Market Dynamics

Advancements in RNA Technologies Driving Growth

The increasing development of stable and functional RNA has boosted circRNA synthesis. Compared to linear RNA, circRNAs offer superior stability and resistance to exonuclease degradation, making them ideal for gene therapy, vaccine delivery, and protein replacement strategies. Technological improvements in circRNA synthesis, editing, and large-scale production are accelerating their adoption in pharmaceutical and academic research.

Rising Demand for RNA-Based Therapeutics

CircRNAs are emerging as the next frontier in RNA-based drug development. Their ability to act as protein templates and regulate gene expression makes them promising therapeutic candidates. Unlike linear mRNA therapies, circRNAs can be engineered to enhance payload capacity and expand applications. Increased preclinical studies and research investments are driving demand for rapid, scalable circRNA synthesis platforms.

Restraints: Lack of Standardization

The absence of standardized protocols for circRNA synthesis, purification, and quality assessment is limiting market growth. The covalently closed loop structure of circRNAs presents unique detection and validation challenges. Non-uniform methods across laboratories hinder reproducibility, scalability, and regulatory approvals, restraining widespread adoption in commercial therapeutics.

Segmentation Analysis

By Product & Service

Reagents & Kits: Dominated the market with 48.25% share in 2024. Essential for high-throughput, accurate, and reproducible circRNA synthesis in both research and clinical settings. Strong interest in academic and commercial research has driven demand for high-quality reagents and kits.

Services: Expected to grow fastest due to increasing complexity of circRNA research. Personalized synthesis, sequencing, and bioinformatics analysis are increasingly outsourced to specialized providers, especially as circRNA therapeutics progress in development.

By Type of Synthesis

Enzymatic Synthesis: Held the largest market share in 2024 due to high efficiency, scalability, and minimal contamination. Methods like ligation and permuted intron-exon (PIE) strategies ensure high yield of biologically active circRNAs.

Chemical Synthesis: Projected to grow significantly, enabling sequence customization and chemical modifications for therapeutic applications. With advances in automation and precision engineering, chemical synthesis is gaining importance in circRNA-based drug development.

By Application

Therapeutics Development: Dominated the market in 2024 due to circRNAs’ stability, low immunogenicity, and translational efficiency. Applications include oncology, cardiovascular diseases, and neurological disorders. Collaborative efforts between pharma companies and academic institutions are further driving market demand.

Drug Discovery: Expected to grow fastest. CircRNAs serve as stable biomarkers and molecular tools for understanding disease mechanisms, facilitating target validation and preclinical studies.

By End Use

Pharmaceutical & Biotechnology Companies: Held the largest share in 2024 due to major investments in RNA-based therapeutic platforms. Strong R&D infrastructure and funding support translation of circRNA research into clinical applications.

Academic & Research Institutes: Expected to grow fastest during the forecast period. Rising interest in gene regulation, disease mechanisms, and cellular signaling drives adoption of circRNA synthesis technologies.

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Regional Analysis

North America: Dominated with 44.6% market share in 2024, led by advanced biotechnology and pharmaceutical infrastructure, funding support, and widespread adoption of next-generation sequencing and transcriptomics technologies.

Asia Pacific: Witnessing rapid growth due to government biotech initiatives, genomic research investments, and collaborations with global pharmaceutical companies. China, Japan, and South Korea are strengthening their RNA research capabilities.

Europe: Emerging as a significant market due to strong pharmaceutical infrastructure, supportive policies, and increasing adoption of RNA-based drugs. Germany, the UK, and France lead research initiatives, fostering market growth.

Latin America & MEA: Moderate growth expected. Awareness of RNA-based technologies, rising research initiatives, and government support for biomedical research are contributing to regional expansion.

Key Players

Synbio Technologies, GenScript, Creative Biogene, OriGene Technologies, Thermo Fisher Scientific, Bio-Synthesis Inc., Twist Bioscience, Syntezza Bioscience, VectorBuilder, Vigene Biosciences, Dharmacon (Horizon Discovery), Eurofins Genomics, Bioneer Corporation, Sangon Biotech, TriLink BioTechnologies, Baseclick GmbH, Integrated DNA Technologies (IDT), Macrogen, GeneUniversal, Genewiz

Recent Developments

• September 2023: GenScript expanded its in vitro transcription (IVT) mRNA synthesis platform, offering tailored circRNA synthesis and lipid nanoparticle (LNP) formulation services.
• August 2024: Abogen Biosciences developed the Cis-Splicing System (Cis-System) for highly efficient circRNA production, marking a milestone in RNA-based therapeutic technologies.

Conclusion

The CircRNA synthesis market is poised for substantial growth driven by technological advancements, increasing demand for RNA-based therapeutics, and strong investments in research. Despite challenges from the lack of standardization, expanding applications in therapeutics, drug discovery, and academic research are expected to accelerate adoption across the globe. Market leaders are leveraging innovations in enzymatic and chemical synthesis methods, supporting the transition of circRNAs from research tools to clinically viable therapeutics.

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