Antisense & RNAi Therapeutics Market Share Anticipated to Climb to USD 3.38 Billion by 2030

The Antisense & RNAi Therapeutics Market Share is estimated to be nearly USD 1.63 billion in 2023 and is predicted to reach USD 3.38 billion by 2030, at a compound annual growth rate (CAGR) of 11% during the forecast period. The primary factors that are stimulating the growth of the gene silencing market are the advancements in technologies and rising investments in gene silencing therapies.



Drivers & Opportunities for Growth in the Market

The antisense and RNAi therapeutics market is experiencing significant expansion due to several key factors. Advancements in nanomedicine have revitalized interest in RNAi therapeutics, enabling more effective delivery mechanisms and enhancing therapeutic efficacy. Additionally, the versatility of antisense technology in modulating gene expression positions it as a promising treatment for a wide array of diseases, including cancer, diabetes, and cardiovascular disorders. Pharmaceutical companies are increasingly investing in research and development to explore gene silencing drugs, aiming to address previously intractable medical conditions. This surge in R&D investment is expected to yield innovative therapies, thereby propelling market growth.

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Segmentation Analysis

The antisense and RNAi therapeutics market can be segmented based on the technology, application, and route of administration.

Market by Technology: It is segmented by RNA interference (RNAi); Antisense RNA RNAi technology (small interfering RNAs and microRNAs), is a dominant part of this aspect of the market, since it can be used to selectively silence genes known to be associated with different diseases.

Based On Application: Therapeutics are used in all the fields like oncology, cardiovascular, respiratory, neurological, and infectious diseases. Oncology is still the largest segment, owing to the large numbers of patients with cancer who need targeted therapy.

Based on the Route of Administration, the introduction include Intravenous Injection, Intrathecal Injection, Subcutaneous Injection and others. By route of administration, the intrathecal injections segment is projected to hold lucrative share, owing to its established utility by operators for the ability to deliver therapeutics directly to the cerebrospinal fluid, which is particularly useful for the treatment of disorders affecting the central nervous system.

Country-Level Analysis

The US is a front-runner in the field of biotechnology innovation and has a large market share of the antisense and RNAi therapeutics market in the United States. Availability of development tools and services coupled with a broad range of target diseases fueled by well-established research infrastructure and significantly high investments, and prevalence of target diseases drive the market growth.

Germany has an extensive pharmaceutical industry, while also focusing heavily on research and development, making it arguably one of the most influential players in Europe. Additionally, the market growth is aided by government initiatives supporting biotechnological innovations.

China: Touted as having some of the fastest growing economies in the world, coupled with generous healthcare expenditure and an enormous patient population, China constitutes an attractive market for antisense and RNAi therapeutics. Market opportunities are bolstered by government policies promoting biotech research and joint ventures with Western pharmaceutical companies.

Japan, with its expert healthcare system and emphasis on innovative biomedical studies, is moving toward becoming a major market for gene silencing therapies. The rise of antisense and RNAi therapeutics is less of a straightforward commercial development story than a tale of collaborations and joint ventures between academic institutions and pharmaceutical companies.

United Kingdom: The growing position of the UK in the antisense and RNAi therapeutics market has been driven by governmental support of biotech startups, both through funding initiatives and favourable regulations. Collaborative initiatives of governments, academia, and industry stakeholders are driving the market towards growth.

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Competitor Analysis

There are several key players who contribute to the antisense and RNAi therapeutics market such as the following:

A clinical leader in RNAi therapeutics, Alnylam Pharmaceuticals developed Onpattro (patisiran) to treat hereditary transthyretin-mediated amyloidosis. A strong pipeline and strategic partnerships highlight its strength in the market.

Ionis Pharmaceuticals: With a focus on antisense technology, this company has a broad portfolio with programs to treat a range of diseases, including neurological and cardiovascular disorders. They already have partnerships and increasing growth with its innovative platform.

GSK plc., as one of world largest healthcare company, GSK has been involved with RNA targeting therapeutics, both in collaboration and in-house to support their paradigm of development in gene silencing therapy.

Sanofi has made several strategic investments and partnerships in the RNAi space demonstrating their commitment to expanding its therapeutic pipeline indirectly into rare disease and oncology.

Benitec Biopharma Inc., is an innovative biotechnology company harnessing its proprietary DNA-directed RNA interference (ddRNAi) technology platform to develop a new class of therapies for patients suffering from chronic and life-threatening conditions, including ocular and neurological diseases.

Exciting industry updates include Alnylam's growing pipeline of innovative CNS RNAi therapeutics and Ionis Pharmaceuticals' antisense oligonucleotide disease-modifying therapies for neurological diseases.

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Conclusion

The antisense and RNAi therapeutics market is set for significant growth, driven by technological advances, partnerships, and increased need for targeted gene therapies around the world. With leading developers marching their pipelines forward and learning from many years of trials and tribulations behind them, the market is ready to change the treatment paradigm for many chronic and genetic diseases.

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